The first stage implements a novel approach, called stochastic subset optimization (SSO), for iteratively identifying a subset of the original design space that has high plausibility of containing the optimal design variables.
Nevertheless, considering the high plausibility and the narrow confidence intervals for the association between Scl and the outcome of interest, we do not believe that this could invalidate our findings.
With N1, N2, N3 being the numbers of participants who voted for low, medium or high plausibility, respectively.
The results show an overall high plausibility which supports the consistency of the developed approach.
For the Black Mirror producers, the design ethos always starts with one question: "What's around the corner?" It imbues each episode with a high plausibility factor, whether it's the futuristic warfare of "Men Against Fire," the warped AR social media landscape of "Nosedive," or the artificially intelligent bees and cyber mayhem of "Hated in the Nation".
In all, the functional consequences of the variants identified as strongly associated with increased risk of normal tissue toxicity following radiation exposure suggest a high biological plausibility for our findings.
Out of the 148 NMDR relationships analyzed, 82 were categorized with this method as having a "moderate" to "high" level of plausibility for various effects.
The fact that with a higher statistical plausibility higher Sigma can be observed for identical sparsity further validates the small-world property as an inherently stable feature of the white matter connectome.
The high expression of SLC2A9 in the epithelial cells of the proximal tubule and the atypical membranes of the kidneys [ 41], along with evidence that SLC2A9 is responsible for transport/re-absorption of uric acid and to a lesser extent glucose and fructose [ 42], provides biological plausibility for the high p-values for the SNPs in this gene in association with uric acid levels.
However, our data identifies complex cis- and trans-acting variants modulating IL-6 expression which are of high biological plausibility, and for ALOX15 provides evidence of association with the expression of other cytokines involved in the acute inflammatory response.
