Sentence examples for high plasma concentrations from inspiring English sources
Abnormally high plasma concentrations of amantadine may elicit symptoms of neurotoxicity and cause seizures and coma.
Moribund gummy sharks had very high plasma concentrations of lactate and potassium.
High plasma concentrations of albuterol were observed in both asthma and COPD patients presenting to the emergency department.
Studies of the adverse effects of NSAID therapy have primarily focused on oral NSAIDs, with the increased risk of adverse effects resulting from high plasma concentrations.
However, these experiments suggest that high plasma concentrations may be achieved in the process, negating the safety advantages of transdermal ibuprofen over oral delivery.
Low penetration through the blood-brain barrier is one explanation to why high plasma concentrations of telcagepant are needed to treat migraine attacks while vascular effects are seen at lower concentrations in vitro [39].
Lessons from the ritonavir development program were integrated into ongoing discovery efforts, and lopinavir, a more potent inhibitor achieving high plasma concentrations when pharmacokinetically boosted by combination with ritonavir, was identified.
In 1966, Laron et al. [41] described a syndrome of familial dwarfism which was indistinguishable both clinically and in many of the laboratory findings from pituitary dwarfism but in which there were abnormally high plasma concentrations of immunoreactive human growth hormone (IR-HGH).
The high plasma concentrations of adrenaline also may cause cardiac arrhythmias (irregularities in the heart rate and rhythm), electrocardiographic changes (in 27 percent of cases) and cardiac arrest (in 3 percent of cases) may occur rapidly after the onset of hemorrhage.
For none of the patients adverse medication reactions were reported In this pharmacokinetic case study high plasma concentrations for OC were achieved in two out of three patients.
High plasma concentrations can be obtained with intravenous administration.
