Exact(2)
These factors are largely unknown, but might include adapter proteins, phosphatases and so on, but it appears that these factors vary in abundance with subtype (for example, HR+ lines are biased toward high pERK response).
In particular, a striking reduction of Ki67 staining was noted for the WM35 cell line when treated with 300 n M U0126, even though high pERK levels were maintained.
Similar(58)
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The lowest tested XE concentrations evoked a higher pERK response than did 10-9 M E2.
Patients with tumour cells expressing higher pERK staining intensity had no improvement in their PFS, TTP or OS.
Moreover, although not statistically significant, there was a trend towards higher pERK expression in the sensitive versus resistant xenografts (P = 0.093).
Tumours with higher pERK (phospho-ERK) expression are marginally more responsive to PD184352, although the overall anti-tumour activity of this drug is insufficient in multiple human cancers [ 5].
The lowest tested BPS concentrations evoked a higher pERK response than did 10 9 M E2; the response steadily decreased with increasing BPS, indicating a nonmonotonic dose response (Vandenberg et al. 2012).
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As MDA-MB-231 suspension cells expressed the highest levels of pFAK and pMEK, but MDA-MB-435 expressed the highest levels pERK, we further investigated the differences in their regulation of MAPK pathway using adhered cells.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com