Sentence examples for high number of mutations from inspiring English sources

Another interesting observation was that while almost all BRCA1/2 mutants exhibit a specific mutational signature, there were also BRCA1/2 wild-type samples with high number of mutations due to this mutational process.

Moreover, our discovery of the uniquely high number of mutations in this tumor may lend insight into its biological behavior.

In some directed evolution experiments, a high number of mutations around 9 12 bp/kb may be obtained (Cadwell and Joyce 1992).

Deep sequencing of PDAC tumors has revealed the presence of a high number of mutations (>50) that affect at least a dozen key signaling pathways.

Interestingly haplogroup A, which is prevalent also in Africa had a very high amount of mutations (43) too, although it has a high number of mutations in gene regions (Fig. 2).

The algorithms for developing the vaccines are most effective for tumors with a high number of mutations, like skin cancer.

Oncogenic insults may result in a high number of mutation rates in cells predispositioned to tumor and the mutation rate increases in cells that have reached replicative senescence.

The hyper-variable region, located in the loop connecting the fourth and the fifth helices in our model, has been shown to be dispensable for Rev activity, however, the high numbers of mutations in this area can result in significant fluctuations in levels of Rev activity in vitro.

Mutations were observed in up to 13,000 genes in these individuals including some common genes with consistently high numbers of mutations.

These numbers suggest that CpG dinucleotides may contribute to the disease process but that this is not the only factor responsible for the high numbers of mutations in this sub-set of amino acids.

High transcription levels of such elements, combined with the high numbers of mutations that they have accumulated, suggests a massive but ancient genome invasion event [ 67, 68] in the E. falcata genome compared to the other three species.