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In all cases, the primary reasons for failing to detect lesions on antibody scan included small lesion size and locally high normal tissue background due either to proximity of the heart or major vessels (lungs) or physiological uptake (liver).
A consequence of this may be that cancers with poor prognosis characteristics are assigned with good prognosis because of high normal tissue content in the sample.
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In recent years, the main goal of all clinical developments has focused on improving clinical benefit, with an increased tumour control and a higher normal tissue protection.
Assuming higher normal tissue sparing by increase of the heavy-ion part of the treatment, we would expect toxicity/mucositis rates unchanged or even lower.
High density normal tissue microarray slides containing 45 normal human tissues in duplicate (AccuMax Array # A103VI-Normal tissues) were purchased from ISU-ABXIS (Accurate Chemical Corp ,Westbury, NY, USA).
Of particular interest was cluster C, spanning 462 genes that were high in normal tissue, immortalised breast epithelium, and PMC42.
Men that had tumours with an MUC-intensity lower or higher than normal tissue had a higher risk of dying in prostate cancer, independent of tumour extent and Gleason score (HR 5.1 and 4.5, respectively).
The conductivity of a malignant breast tumor is typically 0.2 mho which is significantly higher than normal tissue which has been typically measured at 0.03 mho.
Subjects with diabetes have higher than normal tissue factor levels.
As with mammaglobin A, lipophilin B expression was highest in normal tissue from the uterine cervix.
This difference makes temperature of tumor tissue significantly higher than normal tissue under the same heat condition.
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