In bacteria, high mutation rate associated to mutator genes allow rapid adaptation to new selective conditions [58].
The influenza A virus has a high mutation rate and thus a large number of strains.
It's not yet clear why iPS cells have such a high mutation rate.
The high prevalence of polymorphisms indicates a high mutation rate that enables the diversification of the phage populations.
MtDNA is a well-known genetic marker for its high mutation rate, maternal inheritance, and lack of recombination12.
The high CF allele frequency in Europe could only be accounted for by a 'Europe-restricted' high mutation rate or by a 'Europe-restricted' heterozygous CF/+ advantage.
The most plausible explanation seems to be the latter, mainly because a 'Europe-restricted' high mutation rate was judged extremely unlikely, although it was never directly disproved.
This approach combines high mutation rate of the synthetic DNA with the high assembly efficiency of Gibson Mix.
Experimental results obtained have indicated that a high mutation rate increases the success rate, although computational costs are increased too.
HCV has a high mutation rate and multiple genotypes, which have challenged the development of an HCV vaccine.
The high mutation rate of HA sometimes generates new HA subtypes that have never infected humans.
