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For example, in tuning the GA, high cross-over probability typically leads to better performance than high mutation probability.
However, a high mutation probability reduces the searching performance of the random searching algorithm and may go against retaining the better.
In our case, the mutation probability is kept as 12%% because the high mutation probability will change the maximum genes of the chromosome, and the algorithm will relapse into a random search for an optimum.
In order to speed up evolution we chose a high mutation probability (μ = 0.1).
The accrual phase ended in 2011, with the randomization of the planned 150 subjects: 68 ER negative DIN, 50 LIN and AH and 32 subjects with BRCA1 mutation or high mutation probability.
The impact on the process of somatic cancer evolution may be demonstrated by stabilization of the genome architecture despite a high mutation probability or by a permissive effect on further modification of the genome architecture during somatic cancer evolution.
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And when the fitness of the individual is lower than the average fitness, the higher mutation probability is used.
These findings indicate that the high-risk clinical history criteria were effective in identifying patients with higher mutation probabilities.
The standard approach to identify the driver genes is to identify recurrently mutated genes, i.e. those genes whose observed frequency of mutations is significantly higher than the expected passenger mutation probability[ 1- 3].
To enforce that the driver mutation probability is at least as high as the average passenger mutation probability (i.e. that d g > b ¯. g ), we let d g ∼ B e t a truncated below at b ¯. g.
The BRCA1 mutation probability as predicted by the BOADICEA model is high, 40.9%.
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