Sentence examples for high mutation prevalence from inspiring English sources

Seven significantly mutated genes, including four reported (APC, TP53, KRAS and SMAD4) and three novel recurrently mutated genes (CDH10, FAT4 and DOCK2), exhibited high mutation prevalence (6 14% for novel cancer genes) and higher-than-expected number of non-silent mutations in our CRC cohort.

PIK3CA contains a total of five domains, so we compared the domain peaks identified by our method to the domains identified with high mutation prevalence, a measure commonly applied to identify genes mutated in a high percentage of patients.

Three novel recurrently mutated genes, namely CDH10, FAT4 and DOCK2, were identified to exhibit high mutation prevalence in the Asian CRC cohort.

Titin (TTN) was also selected as a non-cancer gene because it has a high mutation prevalence probably due to its massive size.

Besides genes of 5q22.2 and 18q21.1-q21.2 described above, we also investigated genes with high mutation prevalence (i.e., P53, KRAS, and PIK3CA), as well as those with intermediate-low mutation prevalence (i.e., SMAD2 and SMAD3) in human CRC [ 46].

We also did not find significant mutation frequency or high mutation prevalence in the PI3K_rdb, RAS-binding domain, or in the PI3K_C2 domain, which contains signals for the cellular localization of the PIK3CA protein [ 30].

Microsatellite unstable gastric cancer were observed to have a higher mutation prevalence of both C > T transitions and C > A transversions [ 71].

Other ASXL1-related abstracts that were presented at ASH 2010 included c.1934dupG p.Gly646TrpfsX12 as a true mutation and reported much higher mutation prevalence in PMF and post-MDS/CMML AML.

Due to extensive exposure to carcinogens, small cell lung cancer (tobacco) and malignant melanoma (ultraviolet light) show the highest somatic mutation prevalence (over 100/Megabase (Mb)).

Higher KRAS2 mutation prevalences have been reported in pancreatic or duodenal juice (63 to 87%), due probably to higher DNA tumour content in pancreatic juice as compared to plasma (Wilentz et al, 1998; van Laethem et al, 1998; Watanabe et al, 1999).

Indeed, where the overall incidence is low, the contribution of hereditary cases may be relatively high even if the mutation prevalence in the population is comparable.