In fact, it is also possible that this subgroup of patients with higher levels of sensitization would be more susceptible for developing widespread symptoms representing the 35 44% of sufferers with TTH presenting co-morbid fibromyalgia syndrome [27].
Sex differences have been reported for sensitization to psychostimulants in rodents, which is likely related to augmented DA responses [ 249, 250], with females showing a higher level of sensitization than males.
PAHs are also thought to be strong inducers of oxidative stress because the ability of DEPs containing high levels of PAHs to enhance ovalbumin sensitization in mice is inhibited by pretreatment of mice with thiol antioxidants (Li et al. 2009; Whitekus et al. 2002).
From seven hours after sensitization, high levels of chemokines (MCP-1, MIP1α, GRO/KC, RANTES, eotaxin) were found in synovial fluid of arthritic knees whereas perivascular infiltration occurred in the synovium; local release of inflammatory cytokines (IFNγ, IL-1β, IL-6) preceded the spreading of inflammation and resulted in progressive degradation of cartilage and bone.
As shown in this figure, mite sensitization induced high levels of these antibodies when compared to the control group (p < 0.001; Fig. 7a-c).
Protein allergens within the LTP family are known to have high levels of sequence homology and thus IgE cross-sensitization.
The presence of active TrPs indicate sensitization of peripheral muscular nociceptors since high levels of chemical mediators [33, 34] and greater mechanical hypersensitivity [35, 36] have been found in active TrPs.
In addition, the finding on the positive impact of PI3K/AKT inhibitor on the apoptotic effects of cisplatin has provided useful information for the design of sensitization strategy in cervical cancer patients, especially those with high levels of LPA.
