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> > -wrap-foot> The MHC is characterized by high levels of duplication, polymorphism and LD.
The separation of TAP and Class I in mammals has been hypothesized to have resulted in their evolutionary independence and in turn led to high levels of duplication and divergence in Class I genes [ 56].
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The Zygomycete Rhizopus oryzae genome has undergone a high level of duplication [ 14].
For example, although EMAGE and GXD have a high level of duplication (in terms of data), their contents are not identical.
Each of the experimental repeats resulted in a high level of duplication indicated by many reads aligned to the same genomic location, probably due to the low amount of pre-mRNA targets recovered from the nucleoplasm in the CLIP experiment.
For a number of genes, including most SfiI sub-telomeric genes, the closest neighbour was identified as a paralogue located in a different telomere, implying a high level of duplication and recombination within these families.
Gene family expansion in species with overall higher levels of duplication also showed functional trends that could be reconciled with organismal life histories [ 9- 15, 18, 18, 36, 37, 55, 60, 66, 75].
Other economically important families showed higher levels of duplications, which is due to the high sampling intensity in some regions.
First, the amount of repetitive DNA or large scale genomic duplication in the genome being sequenced is a potential concern, with high levels of recent duplication increasing the chances of mistakenly clustering paralogous sequences with alleles at a locus.
Genomics has detected small-scale changes, such as the existence of surprisingly high levels of gene duplication and mobile elements within genomes.
Notably, this map revealed a very high level of dominant RFLP, suggesting that the large genome size of onion is associated with high levels of gene duplication.
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