Aligning the contigs to the reference genome demands a higher level of variant tolerance.
In the case of maxadilan, the high level of polymorphisms elicits variant-specific antibodies with little cross-reactivity, and it has been suggested that sand flies may have evolved diversity in maxadilan as a strategy to evade the host immune response against this essential vasodilator peptide that facilitates blood feeding of L. longipalpis.
Using this approach, a high level of sensitivity and specificity of variant detection were achieved.
Individuals with latent TB infection, but who remain healthy, have high levels of this variant mRNA [ 46].
A high level of expression of a splice variant of NRSF (sNRSF) has been identified in SCLC (Ledermann et al, 1994).
The sex-specificity observed in patterns of expression for some of these genes and the differential expression between mosquito strains are also very unusual features, particularly given the generally very high level of sequence conservation between wPip variants.
These studies indicate that HeLa has a high level of aneuploidy, numerous large structural variants, extensive point mutations and extensive genomic rearrangement, especially at chromosome 8q24.21, the hotspot site HPV-18 genome integration [ 26, 27].
Furthermore, low Piwi-like 4 mRNA expression was correlated with a high level of the survivin Delta 3 splice variant.
Many cancer cell types express high levels of specific variants of CD44 [19].
We aimed to test whether high levels of soluble variants of RAGE could be protective against atherosclerosis development.
