Sentence examples for high level of target from inspiring English sources
Due to their biological function and high level of target specificity, these enzymes are under intense investigation as tools for gene targeting.
The ability to produce a high level of target gene knockdown in the lung with minimal toxicity demonstrates the potential of these lipopolyamines for use in developing RNAi therapeutics for pulmonary disease.
The vectors permit a high level of target expression in E.coli and are mostly derivatives of pET47b (PSPCm2, PSTCm8, PSTCm10 PSPCm11, PSPCm11, NSKn1).
These results indicate that Pluronic-PEI conjugated with DR5-TAT peptide has excellent gene transfection efficiency and a high level of targeting specificity to DR5-positive cells.
Therefore, there is a critical need to develop a novel gene delivery system that can fulfill the special requirements for successful gene delivery, such as high transfection efficiency and low cytotoxicity as well as high level of targeting specificity to cancer cells.
Often they act with other protein-interaction modules to guarantee a high level of targeting specificity for these essential enzymes.
We show that this system can be used in cell culture to upregulate a range of target genes, singly and in multiplex, and that a single guide RNA upstream of the transcription start site can activate high levels of target transcription.
Here we report the development of a class of structurally versatile cationic lipopolyamines designed specifically for delivery of siRNA which show high levels of target transcript knockdown in a range of cell types in vitro.
We also discuss how the production of high levels of target terpene compounds can be achieved in fruits by the expression of individual or a combination of (i) the MEP or mevalonic acid pathway enzymes, (ii) prenyltransferases, and/or (iii) terpene synthases.
Adenovirus-mediated gene therapy holds potential for many diseases, but especially for applications requiring high levels of target tissue transduction.
