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Comprehensive molecular, cellular and systemic-level assays all support a high level of selectivity.
The emerging physiological significance of carbohydrate (glycan)–protein (lectin) recognition engenders the interest to design synthetic inhibitors with a high level of selectivity among natural sugar receptors.
As well as appropriate affinity and bioavailability, putative inhibitors should possess a high level of selectivity for ALR2 over the related aldehyde reductase (ALR1).
The ZME of zeolite Y coated with Nafion was found to exhibit a high level of selectivity for Pb over Cd, with a selectivity coefficient of 0.068.
Moreover, the proposed structure greatly reduces the size and introduces two transmission zeros near the passband edge in the stopband, which results in a high level of selectivity and harmonic suppression.
Out of these, the best was the double variant I80 V/V83L, which induces a relatively high level of selectivity for (R,R -2 (77 % ee).
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Several aryloxyazetidines also showed high levels of selectivity, with one compound, 25, displaying promising in vivo pharmacokinetics and significantly improved aqueous solubility over related compounds containing a biaryl substituent.
This report describes a theoretical study of the 1,3-dipolar cycloadditions between dimethylvinylborane and different chiral nitrones, aimed at identifying the requisite structural features to achieve high levels of selectivity.
Allosteric binding sites, as opposed to traditional orthosteric binding sites, offer unparalleled opportunities for drug discovery by providing high levels of selectivity, mimicking physiological conditions, affording fewer side effects because of desensitization/downregulation, and engendering ligands with chemotypes divergent from orthosteric ligands.
6 One of the most attractive features of enzymes in this respect is their high levels of selectivity.
The use of these nanocrystals displayed high levels of selectivity and specificity in achieving effective cancer cell death without nonspecific toxicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com