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The importance of this class of genes in plant genomes is also demonstrated by the unusually high level of selection found at disease resistance loci [20], [21].
Conservation of these regulatory sites in radial animals such as N. vectensis suggests a high level of selection during the evolution of these phosphorylation sites and therefore the maintenance of their functional relevance.
We chose these two journals because they have published clinical studies in hepatitis and cirrhosis since at least 1945, because they are peer- reviewed with a high level of selection and have a high impact factors greater than 10.
Rather, it is more likely that genes that display a high level of selection at their synonymous sites are preferentially located in closed regions of the genome.
The results demonstrate that the AuPosSOM contact analysis followed by scoring of the compounds using the scoring function developed can provide a high level of selection for active compounds.
According to Jefferies and colleagues, prefrontal cortex, together with temporo-parietal attentional areas, may constitute a complex cognitive control network with an important role in tasks with high level of selection demands, the higher the competition, the higher the demands, the more critical the role of selection mechanisms [see also Peers et al. (2005)].
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Mitochondrial genes are useful markers in reconstructing population histories and comparing patterns of divergence in markers experiencing high levels of selection, such as the MHC [ 14].
Further analysis is therefore required to determine why protein coding genes in closed regions of the genome display such comparatively high levels of selection at their synonymous sites.
Despite rigorous model selection procedures, in rare cases PAML may estimate very high levels of selection over a tiny proportion of a given sequence (even a single site), leading to greatly inflated average levels of dN/dS.
Both treatments in which larvae were exposed to Bt selection (Treatments 1 and 2) displayed significantly higher levels of survival on Bt compared to those where non- Bt broccoli plants were used, indicating high levels of selection against susceptible genotypes in these cages.
The eco-evolutionary dynamics of such systems have been studied in depth in Takeuchi and Hogeweg (2009), where it was shown that travelling waves constitute a higher level of selection than that of individual replicators and parasites.
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