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This strongly suggests that the two silent changes in E1 and NS5B coding sequences are not required for a high level of replication fitness of the chimeric virus.
We selected this data set in because of its relatively high level of replication (six arrays per group) and observations that alternative mRNA processing is unusually prevalent in neural tissue.
A high level of replication makes these results robust.
The high level of replication of each allele in the recombinant inbred lines was exploited to identify single-position polymorphisms that were assigned to parental haplotypes.
Porcine circovirus 2 (PCV2) and chicken anaemia virus are able to maintain a high level of replication up to one month or longer after experimental inoculation (Bolin et al., 2001; Imai et al., 1999) [ 1, 2].
Similarly, our observation that RNaseH overproduction does not decrease the high level of replication intermediates and cell elongation in InvA rep and InvBE rep cells can be interpreted as an increased level of replication-RNA Pol collisions in these mutants.
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These data demonstrate the need for high levels of replication when testing for effects of EDCs on reproductive output in the zebrafish model in an environmentally relevant ('6 × 6') breeding matrix.
Similarly high levels of replication have low fitness as the costs of replication act to restrict fitness.
Nef contributes to high levels of replication and the pathogenesis of primate lentiviruses such as HIV-1 and Simian Immunodeficiency Virus.
Our results demonstrate that both unbound and soil-bound prions maintain high levels of replication efficiency after 1 year (Figure 5) and thus most likely do not lose significant levels of infectivity.
It is very sensitive to the proportion of negative responses, so depends on high levels of replication to guarantee near-monotonic change in observed mean value.
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high rate of replication
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