A high score of over-commitment indicates high level of over-commitment [ 32].
In a few organisms between 35%50%% (G+C), there is a high ratio of frequencies indicating a high level of over-representation.
It is possible that the high level of over-expression diverts energy away from general cellular maintenance leading to weaker membrane structures.
As highly expressed transcripts often display high level of over-dispersion as well as high spatial dependence [ 13], for each sample, we chose the 8000 highest expressed transcripts according to the microarray data.
Building on the insights of John Maynard Keynes, post-progressive postwar economists, such as Nicholas Kaldor, in Britain, and Walter Heller and James Tobin, in the United States, argued that running an economy at high levels of over-all demand and low levels of unemployment created a virtuous circle, in which investment, productivity, and wages would all grow together.
Artificially high levels of over-expressed ADAMTS-12 may saturate proteolytic processes resulting in a decrease in these cleavage products.
ErbB2 is resistant to stimulus-induced degradation and high levels of over-expression can inhibit EGF receptor down-regulation.
The protein encoded by this construct, called M3, showed a non-mitochondrial uniform cytosolic and sometimes nuclear staining with some clusters in case of (rare) high levels of over-expression (Fig 2c).
The use of trastuzumab in UC with gene amplification or high levels of over-expression of ERBB2 has been suggested [ 87], though any defects in the pathway below this would be predicted to lead to resistance.
Particularly high levels of over-charging were reported in non-municipal health centres for first ANC visit and delivery [medians of KES 120 (USD 1.58) and KES 150 (USD 1.97), respectively].
When fused to proteins that form concentrated puncta in either the cytoplasm or nucleus, PSCFP2 fusions do not artifactually interact with other AFP fusion proteins, even at very high levels of over-expression.
