Sentence examples for high level of mutation from inspiring English sources

We next followed the mutation rates of these high-efficiency mutated shoots in all the regenerated transgenic tomato plants with mutations, and found a high level of mutation (30 90%) in T0 plants of both Micro-Tom and Ailsa Craig (Fig. 2a).

The current data makes the possibility that such plasmids have a high level of mutation worthy of further study.

Polyploids, such as hexaploid bread wheat, tetraploid durum wheat, and hexaploid cultivated oat, are easily amenable to TILLING probably because genome buffering enables plants to survive a high level of mutation [ 12- 17, 17].

Difference in these small regions between Celera and GRCh37, between Celera and HuRef, and between HuRef and GRCh37 is 2.92%, 3.19% and 3.60%, respectively compared with 0.08% for the genomic average, reflecting a high level of mutation rate in the intergenic regions.

Although this very high level of mutation clustering could, at first sight, be interpreted as evidence for positive selection, we found that silent substitutions were also frequently recurrent (28 recurrent variants in 13 mtDNA sites), with no substantial difference in recurrence rates between silent and missense mutations (p = 0.19; Figure 5 figure supplement 1).

This is unexpected as intergenic regions such as the STAR loci, which consist of repetitive elements dispersed throughout the genome, would be expected to show a high level of mutation and hence evolve at a higher rate than the conserved functional MLST loci where mutations are observed at a very low rate [ 19].

Similar neoantigen-targeted vaccine approaches were previously tested6,7 in early-phase clinical trials for melanoma, which, unlike glioblastoma, is a type of cancer that has a high level of mutations and neoantigens.

Analysis of six genes revealed a high level of mutations with a density of about one per 60 kb.

In fibroblasts, complex I deficiency was secondary to a high level of mutations (68%) (Fig. 1 D ).

This observation suggests that the two chosen DNA fragments (hspA and glmM) correspond to domains with a high level of mutations and encode proteins with few functional constraints.

All of these methods suffer from a relatively high level of mutations in the amplified DNA (error rate 3x10-5[ 3x10-5[ 13]ghly non-uniform andlification due to thighly fidelity and low processivity of the Taq polymerase, respectively.