Sentence examples for high level of mgmt from inspiring English sources

Tumour cells frequently express a high level of MGMT.

U251 and U87 cells showed low level of MGMT, as previously described [ 14] which might highlight a high level of MGMT promotor methylation, compared with T98G.

U251 cells showing a low level of methyl guanine transferase (MGMT) were highly responsive to the radiosensitizing effect of TMZ compared to T98G cells having a high level of MGMT.

U251 (TMZ-sensitive; low level of methyl guanine transferase (MGMT)) and T98G (TMZ-resistant; high level of MGMT) cells [ 23] (American Type Culture Collection, Manassas, VA) were maintained at Dulbecco's minimal essential medium (DMEM) (Thermo Fisher Scientific) with 10 % Cosmic Calf Serum (CCS, Hyclone, Logan, UT) and added glutamine/pyruvate (HyClone) at 37 °C with 5%% CO2.

Both CHO-9 cells, which are O-methylguanine-DNA methyltransferase (MGMT -deficient, and an isogenic derivative, which has a high level of MGMT -deficiente sand cytotoxic response to β- D -glc-IPM, indicanisogenic the Oposition of guanine is not the critical target for cytotoxicity.

In particular, high levels of MGMT associated with target cells are responsible of resistance to triazenes.

Leukaemia blasts, especially of lymphoblastic leukaemia, show frequently high levels of MGMT activity.

Safety-improved vectors that maintain high levels of MGMT expression may be constructed based on the following principles: choice of enhancer promoter sequences with relatively mild long-distance effects despite a high transcription rate, improved RNA processing (export, stability and translation), and protein design.

High levels of MGMT are reported in the brain and other tumors and correlate with resistance to TMZ.

We have previously reported almost uniformly high levels of MGMT in breast tumours as determined by functional assay and immunohistochemical analysis (Clemons et al, 2002).

Many tumours express high levels of MGMT (Chen et al, 1992; Citron et al, 1994) and dose-limiting toxicities occur in the bone marrow, which expresses low levels of MGMT (Gerson et al, 1985).