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It is now fully accepted and of a high level of evidenced medicine that in cerebral hypoxia (in a patient with cardiac arrest due to a shockable arrhythmia) as well as asphyxial encephalopathy a 24-hour therapeutic hypothermia (33 to 34°C), irrespective of the type of cooling, improves neurological outcome; that is, morbidity but also mortality [ 7, 10].
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Randomized controlled trials (RCTs) are considered the ideal and highest level of evidenced based medicine [ 9].
In evidence-based medicine, meta-analyses are often considered to provide an exceptionally high level of evidence.
Despite this progress, the current management of circulatory compromise depends primarily on experts' opinions rather than high level of evidence.
There is value in designing clinical trials so they will be considered to provide a high level of evidence.
A murder charge "requires a very high level of evidence," and the case's complexity and the lack of a witness or forensic evidence "mean proof beyond a reasonable doubt is very difficult to achieve," she said.
High level of evidence of the effect of sucking habits on orofacial structures is missing.
However, only two studies had a high level of evidence at low risk of bias.
Among neuromodulators used for migraine prevention, topiramate has a high level of evidence-based efficacy.
There is a high level of evidence that physiotherapy is effective for headache reduction.
Unfortunately, the number of studies investigating CrossFit with high level of evidence at low risk of bias is sparse.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com