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Our major focus for this study was therefore to simply document that standard dosing assumptions regarding infliximab may lead to erroneous conclusions regarding its cost, given the high level of escalation seen in this and other studies.
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Mr Ient said: "Black alert is a hospital's highest level of escalation, which means that a number of actions will be considered including opening day units overnight and postponing planned surgery".
This same model tested in our current trial's design allowed high levels of dose escalation in previous phase I trials for SABR treatment of liver metastases using 3 and 5 fractions.
This study demonstrates a high level of efficacy of our protocol and the feasibility of de-escalation to limit the number of pharmacologic interventions.
We can only speculate the reasons for these variations, which could be related to awareness that the high level of activity was transient and did not warrant evoking the level 4 escalation procedure.
High level of salt.
Moderate to high level of fitness required.
Nanzhao attained a high level of culture.
He has a high level of energy".
"They discovered a high level of competition".
Apart from routine or near routine encounters, the report identifies "11 serious incidents of a more aggressive or unusually provocative nature, bringing a higher level risk of escalation".
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