This study was designed to assess genotoxic damage in somatic cells of workers in a Polish battery plant after high-level occupational exposure to lead (Pb) and cadmium (Cd), by use of the following techniques: the micronucleus (MN) assay, combined with in situ fluorescence hybridization (FISH) with pan-centromeric probes, analysis of sister chromatid exchanges (SCEs), and the comet assay.
High-level occupational exposures to some industrial chemicals have been associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD).
High-level occupational exposures to industrial chemicals have been associated with liver diseases, including NAFLD (Cave et al. 2007; Cotrim et al. 1999, 2004).
Futhermore, we will use this method to evaluate larger populations with high-level occupational exposures (e.g., manufacturers, farmers) and background exposures in the general U.S. population.
The combination of cigarette smoke and high-level occupational asbestos exposure produces a synergistic increase in the incidence of lung cancer; however, smoking does not affect the incidence of mesothelioma.
What is certain is that regulatory resources targeted at continuing high-level occupational exposures would be much more likely to have beneficial public health consequences than continued attempts to assess low-exposure risks quantitatively.
Recent reviews have noted neurologic sequelae of pesticide exposure among farmers (Jamal et al. 2002a; Kamel and Hoppin 2004), and in the past decade strong associations have been reported between high-level occupational exposure to pesticides and an increased risk of depression (Amr et al. 1997; Farahat et al. 2003; Stephens et al. 1995).
Affected watermen had had constant, high-level occupational exposure to areas of the Pocomoke River where the dinoflagellate Pfiesteria (Burkholder et al. 1992) had been identified in association with several fish-kill events, and it was hypothesized that these river exposures contributed to the observed health effects (Grattan et al. 1998; Morris 2001).
In contrast, among men with a high level of occupational physical activity level exposure to occupational heavy lifting made no difference in the risk of IHD.
Compared to men with high level of occupational physical activity level and no lifting activities, those with low occupational physical activity who were exposed to occupational heavy lifting had a higher risk of IHD HRR = 2.56, 95% CI: 1.52, 4.32).
However, it is unknown if the observed elevated systolic BP at home and during sleep among persons with high level of occupational physical activity and lifting of heavy loads are caused by these occupational physical exposures.
