The RESOURCE_RELEASE procedure releases the excess time slots to its parent for use by the higher level clusters.
In this example, the higher level clusters, with the CID number 1 and 2, can correspond to two different neighborhoods.
In some applications, we find that module eigengenes can be organized into higher level clusters which we refer to as meta-modules.
Unsupervised two-dimensional hierarchical clustering of the 200 most differentially methylated probes (SD 0.2583) within the 101 UC showed that of the two highest level clusters (Fig. 1), the cluster on the left contained a majority of S UC (45 superficial of 58 total) whereas the right cluster had a majority of MI UC (24 MI of 43 total).
Unsupervised clustering of the 200 most differentially methylated probes (SD 0.2242) after filtering within the 101 UC showed that of the two highest level clusters (Fig. 2), the left cluster had a preponderance of S UC (9 MI, 26 S) whereas the right cluster was more even (28 MI, 38 S).
There have recently been a handful of algorithms which construct hierarchies with overlapping clusters, by creating a first level of overlapping clusters with terminal nodes and then combining these base clusters into higher level clusters (Becker et al., 2012; Kovacs et al., 2010; Kumpula et al., 2008; Sales-Pardo et al., 2007).
However, these methods restrict each higher level cluster to having a single parent.
PROP shares a fused ring structure with 2A5C and MDOB, and these three substrates share a common higher level cluster.
To a lesser extent, 2PE resembles 12-pNCA and 11PA in its phenolic ether structure, and it falls into a higher level cluster with these two substrates.
The similarity of the CDR3 sequence logo was even more impressive when concentrating on a higher level cluster of 11 CD4+ T-LGL cases that are all characterized by TCRVβ13.1-Jβ1.1 rearrangements.
