Exact(5)
Both forms of chitosan-modified PLGA nanocomposite particles exhibited a high inhalation efficiency, i.e. more than 50% of the two types of nanocomposite particles could be deposited in the deep lung of male Wistar rats.
To conclude, controlled release DNase I loaded PLGA-MP with high inhalation indices and enhanced mucolytic activity on CF sputum could be obtained by surface modifying the particles with PGA or dextran.
In contrast, there can be high inhalation exposure through aerosols during spray application.
In contrast, the gold miners were likely to have relatively variable exposures to inorganic mercury, with episodes of very high inhalation exposure [ 25, 26, 41].
The significance of U-Cd as a marker of Cd body burden was established in the 1980s based on observations of industrial workers with high inhalation exposures (Lauwerys et al. 1979; Roels et al. 1981b).
Similar(55)
Air dust containing TiO2 NPs may result in higher inhalation absorption and subsequent translocation of TiO2 NPs into the circulatory system.
Third, since children have higher inhalation rates per unit of body mass than adults [ 18], they remain disproportionately vulnerable to Pb exposure via inhalation pathways.
Children tend to have higher PAH exposure to air, soil, and dust than do adults because of child-specific behavior patterns, such as hand-to-mouth activity and more time spent close to and on the ground, as well as having a higher inhalation rate on a per unit body-weight basis compared with adults (Committee on Environmental Health 1999; Landrigan et al. 1998).
At high concentrations, inhalation of volatile or low-MW hydrocarbons can cause irritation of the respiratory tract and central nervous system depression.
This was presented descriptively using Kaplan-Meier graphs for reliever use thresholds of >4 (low use), >10 (medium use), and >20 (high use) inhalations in a single day for both treatment groups, with ≥0 inhalations (i.e. all patients) as a reference group.
Chronic high-dose inhalation of carbon black (CB) can produce carcinomas in rat lungs.
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