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Additional subgroup analyses were also conducted due to high heterogeneity between studies.
The dendrograms generated demonstrate high homogeneity within the clusters and high heterogeneity between the clusters (Sarbu and Pop 2005).
In case of limited availability of studies or high heterogeneity between the available studies, no MTC or indirect comparisons should be performed.
Nevertheless, the data on RBCT in patients with sepsis are sparse and the high heterogeneity between studies prevents from drawing any definitive conclusions.
However, results issued from this latter meta-analysis show a high heterogeneity between studies related to various conditions, abnormal cut-off values and measurement timings.
The high heterogeneity between studies is likely due to the wide range of total overdose events reported among the four studies.
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The reasons for this higher heterogeneity between microvascular beds in sepsis than in our model reperfusion injury are uncertain but might be related to different mechanisms of damage as well as the modality of resuscitation (colloid or crystalloid solutions vs. blood).
Objective To examine whether excluding patients from the analysis of randomised trials are associated with biased estimates of treatment effects and higher heterogeneity between trials.
There was no statistical difference between study groups with a high heterogeneity level between studies (I2: 85%).
In labeling sets that contain vinculin (sets A and D) a high heterogeneity exists between cells regarding the abundance of signatures A2, A3, A8 and A9 in focal-adhesions (Supplementary Fig. S6).
Following standard guidelines, I values greater than 50% are considered high heterogeneity levels, between 25-50%, moderate and less than 25%, considered low heterogeneity levels.
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