The high grade of severity of reported pain among our participants would probably be expected with our participants being active users of the health service because of their pain.
These observations corroborate and extend previous reports on HPV16 [ 20, 21, 25] and HPV18 [ 25, 29, 30] demonstrating that while some CpG sites in HPV16 may be weakly associated with increasing cervical disease severity, HPV18-associated high grade cervical disease is characterized by broad CpG site methylation of a high magnitude.
These precancerous lesions are defined as cervical intraepithelial neoplasia (CIN), and classified as low grade (CIN 1) or high grade (CIN 2 or CIN 3) according to severity.
The severity of morphological changes was categorized in two groups: normal or slight changes were considered as low grade and moderate or severe ones as high grade.
The difference between the sexes in terms of severity of acne was statistically significant, with females having a higher grade of acne severity compared to males (Χ=5.97, P=0.03) (Table 1).
One group proposed classifying the severity and treatment of leaks into low grade and high grade, suggesting that complex leaks and high-grade leaks are better treated with a combination of biliary sphincterotomy and transpapillary biliary stent placement [ 3].
These guidelines recognize the following histological classifications of BE in order of increasing severity: intestinal metaplasia, "indefinite for dysplasia", low grade dysplasia (LGD), and high grade dysplasia (HGD).
Histological grade is defined by the SEER Program Coding Manual and by the International Classification of Diseases for Oncology, Second Edition in increasing level of severity as either low grade (well differentiated), medium grade (moderately differentiated), or high grade (poorly differentiated) [ 15, 19].
When grouped according to severity of disease using the Bethesda classification, there were 72 with low grade lesions (LGSIL) and 164 with high grade lesions (HGSIL).
This is a four-grade scale with higher grade indicating more severity [ 28].
