Sentence examples for high grade proliferation from inspiring English sources

Human breast tumours that are COX-2 positive have high grade, proliferation and oestrogen receptor (ER -negative status, and arER -negative with statusr time to recurrence and deare [ 4].

Considering the slow proliferation feature of the plasma cell, we believe that patients who had positive results in G-banding, either hyperdiploid or hypodiploid, had high-grade proliferation and therefore would have worse survival than patients of the normal karyotype.

This is especially important in HR-positive/HER2-negative HR-positive/HER2-negative HR-positive/HER2-negativeiferation and good patientss tumour from high grade, high proliferation and poor prognosis tumour and is consequently a central determinant of the treatment scheme.

Tumour grade as defined by Elston and Ellis is a central node of the treatment decision-making process in HR+/HER2− breast carcinoma as it discriminates low grade, low proliferation and good prognosis tumour from high grade, high proliferation and poor prognosis tumour.

Elevated Src expression is frequently observed in human breast cancer tissues compared with benign breast tumors or adjacent normal breast tissues and this elevated Src activity has been correlated with high grade, high proliferation and HER2 positivity in DCIS [34] as well as with poor metastasis-free survival in invasive breast cancers [35], [36].

According to this hypothesis, hallmarks of the type II pathway are high grade, high proliferation index, and p53 mutations (Shih and Kurman, 2005; Singer et al, 2005).

It is also being used increasingly in those that present with operable breast cancer but aggressive pathological features (high grade, high proliferation, triple-negative or HER2-positive breast carcinoma).

Unfortunately, ER negativity is frequently combined with other characteristics of biological aggressiveness (high grade and proliferation, overexpression of HER2/neu), resulting in a worse prognosis [ 2, 3].

A high grade and proliferation rate of TN tumors has been reported in many previous studies [ 15, 28, 37, 42, 43].

Invasive breast carcinomas without the protective effect of hOGG1 are clearly associated with aggressive features of breast carcinomas, including high grade, increased proliferation, lymphatic vessel invasion and steroid receptor-negative disease.

COX-2 over-expression in human breast cancers correlates with several parameters that are characteristic of aggressive breast disease, including large tumor size, high grade, high proliferation, hormone receptor negative status, and over-expression of HER2 (human epidermal growth factor receptor 2; also called neu and c- ERBB2) [ 13, 24, 26, 33].