OS was adversely affected by the presence of p53, high grade features, increased mitotic activity, and inflammatory presentation (stage IIIB), while overexpression of HER2/neu showed a trend (P=0.06) toward predicting shorter survival.
There is also a well-documented predisposition for LS-associated tumors to exhibit high grade features with a mixed histology which can at times represent a huge challenge to anatomic pathologists attempting to subtype the tumor components into the various neat categorical variants [ 41, 42].
Follicular lymphoma (FL) is the most common type of indolent B-cell lymphoma, accounting for 10 20% of all malignant lymphomas (MLs) 1. FL is characterized by frequent relapses and progression to treatment-resistant disease or transformation to high-grade feature, despite initial responsiveness to chemotherapy or radiotherapy 2, 3.
Conversely, in 40% of diseases FNAC suggested high-grade features on smear.
Parotid fine needle aspiration biopsy revealed diffuse large B-cell non-Hodgkin lymphoma with high-grade features.
The tumors exhibit a primarily astrocytic morphology, and frequently harbor high-grade features, such as microvascular proliferation and pseudopalisading necrosis.
In the general population, high-grade features predominated until approximately age 40 years, whereas low-grade BC was more common at older ages.
Based on the histopathological data, 23 patients were diagnosed as having a tumor with low-grade features (grade II) and 14 patients were diagnosed as having tumor with high-grade features (grade III).
Furthermore, when v-erbB overexpression is paired with Ink4a/Arf loss, tumor incidence increases to nearly 100% in 12 months, and high-grade features predominate.
The series of analyzed cases did not include poorly- or undifferentiated thyroid carcinomas, and none of the TP53 mutated cases had significant mitotic activity or high-grade features.
As in other models, loss of tumor suppressors like Ink4a/Arf and Pten dramatically decreases disease-free latency and increase the appearance of high-grade features (12).
