Sentence examples for high grade cases from inspiring English sources
High grade cases F and I had an average methylation of 72% and 43% respectively, across all 27 CpG dinucleotides analyzed, while low grade samples 4 and 8 respectively had an average methylation of 19% and 35%.
LCN2 was not detected in our cohort of serous ovarian cancer which is likely due to the predominance of high grade cases in our cohort since Lim et al. [52] have shown that LCN2 was expressed at low levels in high grade ovarian cancer but moderate to strong levels in tumors of low grade and/or low malignant potential.
Interestingly, although activating point mutations in KRAS in ovarian cancer are observed predominantly in low grade serous subtype and rarely in high grade cases, of the 25 samples with an amplification at KRAS of at least 0.8 (log2) in amplitude, all but one were high-grade serous, suggesting an alternative mechanism for activation of this pathway in a subset of high grade serous carcinomas.
These differences were more pronounced for high grade cases.
†Index date for high grade cases is date of cytology test immediately preceding the histology test.
†Exposure odds ratio (ratio of exposure odds among high grade cases to exposure odds among controls).
"Other cases" were those women who did not meet the high grade case definition but had any other abnormality (either a low grade abnormality at histology or an abnormal cytology result that was not confirmed by histology).
We took the index date to be the date of the abnormal cytology test result immediately preceding the histology test result satisfying the high grade case definition, because from that point women entered a phase of diagnostic testing.
Serum Mg levels were significantly lower, while the Ca/Mg ratio was significantly higher, among high-grade cases vs. controls (p = 0.04, p = 0.01, respectively).
Accordingly, the Ca/Mg ratio was significantly higher among high-grade cases compared to controls (p = 0.01) and PIN cases (p = 0.05).
We then randomly selected from our available recruitment 101 high-grade prostate cancer cases (Gleason = 7(4+3 only), 8, 9, or 10) and 100 low-grade prostate cancer cases (Gleason = 6) such that the PIN, low-grade, and high-grade cases had an age distribution between 50 80 years and had a similar age distribution using 5-year age categories.
