Both spectroscopy and perfusion-weighted imaging may help to locate high-grade areas [ 4].
Importantly, the additional presence of nuclear staining was significantly higher in tumour tissue (Fig 1C), and strong nuclear ARRB1 was seen in high-grade areas of the tumours (Fig 1A and Supplementary Fig S1E).
Radiolucent regions identified on CT within the dense tumor mass may be due to fibrous, cartilaginous, fatty or benign entrapped soft tissue, or dedifferentiated, high-grade areas of tumor.
Although histopathology is essential in the diagnosis and staging of tumor, grade III gliomas are often heterogeneous and have different degrees of malignant degeneration within the same lesion; 17 missing the high-grade areas during the biopsy could lead to an underestimation of the actual degree of neoplasm.
However 13 of 24 (54%) tumors examined in transgenic mice exhibited areas of variant histology, including areas of clear secretory change, areas of high nuclear grade, areas of oncocytic change and areas of solid proliferation.
Advanced breast cancers are often high grade with necrotic areas, and become more heterogeneous after treatment, with inflammatory infiltrate, oedema, fibrosis and necrosis.
Because the agricultural land in the area is of high grade and the forested areas have scenic beauty and resources, the conversion of agricultural and forestland around the urban center of the province cannot be equated with urban sustainable development indicators.
Large kidney tumors (0.9 × 1 cm) were isolated from control untreated mice and presented histologically as a highly vascularized, high grade carcinoma with some areas of necrosis.
Conventional histopathological as well as molecular studies of breast cancers with "basaloid" differentiation have shown that basal-like tumors are often high grade [ 6], have areas of necrosis [ 7], may have a typical or an atypical medullary phenotype [ 8] and have a distinct pattern of genetic alterations [ 6], including frequent TP53 mutations [ 2].
In October 2004, an outbreak of diarrhea and vomiting with high grade fever hit this area.
Significant predictors of central obesity included higher grade, urban area with high socioeconomic status (SES), high-income neighborhood and higher parental education.
