The margin guideline is applicable to subsets of patients with "bad tumor biology" (triple negative, Her 2 positive, high grade), young age, lobular cancer, EIC, or not receiving systemic treatment.
We observed variation in estimates across age strata, with significantly reduced odds of full vaccination in high grade cases aged 15 to 18 years and 19 to 22 years, and little evidence of any vaccine effect among vaccinated women in the oldest age stratum (exposure odds ratio 0.95, 95% confidence interval 0.63 to 1.45).
The study has also provided new more detailed information than has been reported to date on the pattern of the relative prevalence of HPV 16 and 18 infections in high grade lesions by age.
We identified serum microRNAs able to discriminate patients with high grade SEOC from age-matched healthy controls.
We assessed seroprevalence for HPV16/18 from a population-based sample of 3,729 women with normal cytology and 971 women with confirmed high grade abnormalities (CIN2/3), aged 30 64 years, unvaccinated, and recruited in New South Wales in 2006 2010.
Basal-like breast cancer is associated with higher grade, younger age, higher probability of node involvement and poor prognosis [11], [24], [25].
Interestingly, a recent study found that ER+ cancers which develop in BRCA2 carriers are of higher grade than age matched ER+ sporadic cancers [ 40].
Conclusion: ESR1 amplification as detected by MLPA is rare in breast cancer, and seems to be associated with high ERα expression, high age, high grade and high proliferation.
In the evaluable OC patients, high pre-treatment levels of serum sCXCL16 associated with older age, high grade tumours, and >2 cm residual tumour after primary debulking (Table 1).
The presence of high numbers of FOXP3+ TILs was significantly associated with young age, high grade, estrogen receptor (ER) negativity, concurrent CD8+ cytotoxic T-cell infiltration, and human epidermal growth factor receptor-2 positive (HER2+)/ER− and core basal subtypes.
