"high frequency usage" is correct and usable in written English.
You can use it whenever you want to describe the level at which something is used, especially something used on a regular basis. For example, "The new software has seen high frequency usage since its launch."
Moreover, of the 12 silent mutations that may be at fixation (Figure 2), 75% of them generated synonymous codons with high frequency usage in C. trachomatis [25].
Similarly, we have found that 75% of all silent mutations that are likely at evolutionary fixation resulted in synonymous codons with high frequency usage in C. trachomatis [25].
The high frequency usage of these codons may be a common feature of RP genes.
Systematic single-codon substitutions of five low-frequency codons in a linker region of the Echinococcus granulosus fatty acid-binding protein 1 (EgeneP1) gene to synonymous higher frequency usage codons significantly impacted protein solubility [ 49].
Dynamically sorting apps based on high-frequency usage.
"Food delivery [in India] is a $6 billion market, which is completely mobile app driven, focused on the young working-age population with high-frequency usage," says Sumer Juneja, who led the round for NVP.
The current business model is freemium based, with pricing that kicks in for higher-frequency usage at scale.
Interestingly, the second codon position immediately following the initiation codon, AUG, is more likely to be a high-frequency-usage codon, and thereby, would be translated more quickly.
In unicellular organisms, high-frequency-usage codons correlate with abundant cognate isoacceptor tRNA molecules and have evolved to optimize translational efficiency [ 6– 10].
Computational analysis of the available E. coli genome and protein structure databases identified that high-frequency-usage codons are mainly associated with structural elements, such as alpha helices, whereas clusters of lower frequency usage codons are more likely to be associated with beta-strands, random coils, and structural domain boundaries [ 47].
TCR BJ1-1, 1–2 and 3 7, which are located on the edge of the porcine TRBD-J-C clusters, showed a high frequency of usage when the expression of the detected TCR BJ segments was determined26.
