The upstream sequence of Gata3 contains a high frequency of potential XREs boxes, while Ahr activation suppresses the Th2 differentiation.
Similarly, studies in the bronchoalveolar lavage fluid of healthy adults have shown a high frequency of potential 'pathogens', including Pseudomonas, Streptococcus, Prevotella, Fusobacterium, Haemophilus, Veillonella, and Porphyromonas [ 4].
They observed that the empirical frequency of the stop codons did not differ significantly between phases, whereas start codons were more frequent in phase 1 overlaps, and suggested that the higher frequency of potential start codons in phase 1 would favor the formation of overlaps by 5′-end elongation of gene 2, increasing long phase 1 overlaps.
Identification of high frequency of mutations in potential epigenetic regulators (DNMT3A, TET2, IDH1, IDH2, ASXL1, and UTX) is particularly interesting.
The high frequency of occurrence, the potential for global pandemics and the economic burden of influenza infection warrant the need for a better understanding of influenza pathogenesis and the host response so that new antiviral medicines can be developed.
Concomitant treatment of HIV and TB presents a series of challenges, including a long treatment duration, high frequency of drug administration, potential complex interactions of the drugs, toxicity of the two therapies, and the occurrence of immune reconstitution syndrome [ 7, 8].
This is seen in the high frequency of TpC* mutations in potential "driver" mutations, including missense TpC* mutations in well-known genes such as KMTD2 and ATM shared across all tumours of a patient (Additional file 6: Table S2).
The high frequency of prescription of drugs with potential drug interactions showed in this study suggests that it is common practice in primary care level.
Developing quality measures for breast cancer surgery is critical given the high frequency of surgical breast procedures and potential variation that exists across facilities and surgeons.
It is possible to conclude that the high frequency of prescription of drugs with potential drug interactions is common in primary care level; the easiest way to reduce the frequency of them is to decrease the number of medicines prescribed.
The high frequency of Kit immunostaining in SCLC has important potential therapeutic implications.
