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Processes in manufacturing and logistics are characterized by a high frequency of changes and fluctuations, caused by the high number of participants in logistic processes and the variety of goods handled and services offered.
The high frequency of changes in FLT3 status at the time of relapse (26%) is consistent with previous reports, and supports the need for retesting all relapsed patients for FLT3 status.
This study has shown a high frequency of changes in the pneumococcal carriage in the same child and reinforces the concept that carriage of a specific isolate is very limited in time.
Patients admitted to an intensive care unit (ICU) are at high risk for medication errors and related patient harm (preventable adverse drug events (preventable ADEs)), due to the critical nature of their illnesses, polypharmacy, use of high-risk drugs, and a high frequency of changes in pharmacotherapy [ 4- 10].
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Overall, there appears to be a relatively high frequency of change in DHD, even in the last weeks of life.
The amount of copy number changes found in the YRI population doubles that of any of the other individual populations, and is concordant with previous observations of higher frequency of changes for small, intermediate and large-scale variants and insertion/deletion polymorphisms [35], [53].
The only case when it is outperformed is for low number of participating STAs (Figure 5(b)) and high frequency of rate changes (time interval between rate changes less than 200 sec).
The excess of parallel changes for distantly related species observed in this paper reverberates with the recent finding of a high frequency of parallel changes in evolving protein sequences from mammalian, fruit fly and yeast species [ 48].
A high frequency of polymorphic changes on apparent disease-causing alleles complicates the interpretation of the effects of mutations.
Other studies have demonstrated that a high frequency of internal changes is likely to adversely affect employee health and sickness absence, by further impairing working conditions [ 35, 36].
Considering the high frequency of genetic changes that occur in bacteria and their clonal mode of reproduction, the process of basic laboratory maintenance can easily generate severe bottlenecks of significant consequence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com