Sentence examples similar to high frequency administration from inspiring English sources

The studies discussed also indicate that high-dose, high-frequency administration of s.c. IFN-β-1a is more efficacious than low-dose, low-frequency administration.

Novel platforms combining controlled release, improved adhesion, tissue penetration, and selective intestinal targeting may overcome these issues and potentially diminish the toxicity and high frequency of administration associated with conventional oral delivery.

The differential β-subunit gene expression is regulated by differing GnRH pulse-frequency: increasing pulse-frequency stimulates LHβ gene expression, and lowering it results in a decline in LHβ but a rise in FSHβ expression; the expression of αGSU is less stringently regulated and is stimulated by continuous or high frequency GnRH administration [1] [4].

This high frequency of administration relates to a short plasma half-life (∼3 h) and poor potency (in vitro IC50 values of 81 693 μM), although the action of the immune system also contributes to in vivo activity.

From a public health perspective, however, the point of greatest concern regarding OM and COPD is the high frequency of antibiotic administration, leading to the development of multiply resistant isolates [ 6, 7].

Concomitant treatment of HIV and TB presents a series of challenges, including a long treatment duration, high frequency of drug administration, potential complex interactions of the drugs, toxicity of the two therapies, and the occurrence of immune reconstitution syndrome [ 7, 8].

At the end of the follow-up CINCA patients had required a higher frequency of administration and a trend towards the need for a higher median dose (3.7 vs 2.1 mg/kg) (Table 3).

At the end of the follow-up CINCA patients displayed a higher frequency of administration with a median dose of 3.7 mg/kg (2.1 mg/kg for MWS patients).

Adverse effects were observed in the initial studies when the dosing schedule was not yet well established and the higher frequency of administration of TU led to higher-than-normal levels of testosterone.

High-frequency iron administration and high-dose IV iron administration could be associated with an increased incidence of bacteremia.

The relatively high frequency of opiate and sedative administration despite deep sedation in anticipation of interventions and for diverse medical reasons (for instance, fighting ventilator and heart-lung interactions) represents further evidence of the problems associated with current sedation scores.