Sentence examples for high frequencies of mutations from inspiring English sources

To generate a mouse GIC line, we first transfected NSCs from Prom1lacZ,DTA/+ CreERTM line with pBabe-Puro-SV40LT vector, which blocks both p53 and Rb pathways, as high frequencies of mutations in p53 (87%) and Rb (78%) pathways are seen in human GBM [23], [24].

High frequencies of mutations in BRCA1 and BRCA2 have already been observed in breast cancer patients of African ancestry from Nigeria [ 7] and from the Bahamas [ 8].

Although resistance to α-cypermethrin has yet to be reported in Guerrero, high frequencies of mutations in the voltage-gated sodium channel gene, which is associated with pyrethroid resistance in Ae. aegypti mosquitoes, have been reported (13 ).

Alternatively, changes in the copy number of simple repeats at bacterial contingency loci can generate high frequencies of mutations in particular genes [ 2], but result in a limited range of potential mutations.

However, too-strict filtration of alignments by Gblocks would delete regions with high frequencies of mutations, which in turn would make the calculated substitution rate lower than the actual mutational rates.

First, they incorporate mechanisms designed to produce very high frequencies of mutation, and second, none of the genes involved in the functioning of the immune system are germ-line.

High frequencies of mutation have been observed in isolates from chronic clinical infection with other bacterial pathogens including Stenotrophomonas maltophilia [25] and Pseudomonas aeruginosa [26].

Their activity is normally restricted to the germ line, where it causes hybrid dysgenesis, a syndrome of abnormalities that includes temperature-sensitive sterility and high frequencies of mutation and chromosome breakage (Kidwell et al. 1977).

Mutational screening revealed a high frequency of mutations.

This high frequency of mutations could, however, impede our antibody identification if mutations occurred in PCR primer-binding sites.

We identified a high frequency of mutations in PTEN (50%) and genes involved in the endometrial cancer-related molecular pathway, which involves the IL-7 signaling pathway (PIK3R1, n = 1; AKT2, n = 1; FOXO1, n = 1).