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At 24 h after 131I administration, all of these genes were upregulated with high fold changes (21 180) after 8.5 Gy, while two genes were upregulated to low extent after 17 Gy.
Those genes displaying high fold changes in gene expression (and, hence, in mRNA abundance) potentially represent the most important functions in the biological system.
Statistical analysis also suggested Dnmt3a, Itga6, and Shc1, however high fold changes were measured for these genes in tumor cells as discussed above.
In all, 43 proteins exhibited exceptionally high fold changes.
This huge range of RNAseq data can result in many false high fold changes.
These genes were characterized by extremely low p-values and relatively high fold changes.
Similar(35)
From these, the common list of genes with a high fold change across all time points and across all three fermenter runs was identified (Additional file 3).
We predict that these genes are also NF-kB targets and will produce a high fold change.
The Pou5f1 gene exhibited a high fold change (2.75) in the transgenic state, which had decreased in the tumor state (fold change 1.70).
Independent QRT-PCR assays were performed for the genes which showed high fold change and/or have a direct or indirect relation with skeletal muscle wasting.
However, even these genes did not have high fold change.
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