Or turn instead to a high-protein, high-fat regimen like the one popularized by Dr. Robert C. Atkins?
Responding to years of criticism from scientists that the Atkins version of a low-carbohydrate, high-fat regimen might lead to heart disease and other health problems, the director of research and education for Atkins Nutritionals, Colette Heimowitz, is telling health professionals in seminars around the country that only 20percentt of a dieter's calories should come from saturated fat.
Although SWCNT exposure was not associated with changes in the animals' lipid profiles, the exposed mice on the high-fat regimen did exhibit accelerated plaque formation in the aorta and brachiocephalic arteries compared with controls.
However, the high fat diet regimen prevented chronic fluoxetine treatment from reversing UCMS-induced depression-like behaviour.
A high fat diet regimen inducing hypercholesterolemia is considered as a risk factor for the development of atherosclerosis.
In a recent study with rhesus macaque, Wilson and coworkers [51] showed that subordinates gained more weight and dominants gained less weight than controls under both low and high fat dietary regimen and that subordinates were hyperphagic.
In this test, where the effect of the food texture was excluded as an explanation to the observed effects, only the high fat diet regimen can explain the fluoxetine resistance in reversing motivational and self-care behaviour.
However, in all these behavioural tests, a high fat diet regimen abolished the ability of the AD fluoxetine to reverse UCMS-induced depressive-like state at the end of the second period of the UCMS procedure.
We suggest that a naturalistic animal model of AD resistance related to sub-nosographic clinical entities, associating UCMS with cardiovascular risk factors, especially a high fat diet regimen, could prove to be extremely useful.
Furthermore, since cardiovascular risk factors are related to AD resistance, the association of the UCMS procedure with a cardiovascular risk factor known to induce hypercholesterolemia in mice such as a high fat diet regimen provides a powerful tool to describe a model of "treatment-resistant depression".
