High expression of the system L amino acid transporter has been observed in clinically important tissues including tumors and the blood-brain barrier.
An improved prognosis was observed for patients with tumors displaying high expression of immune system related metagenes which supports recent reports [ 20, 23- 25, 27, 39, 40, 52, 53].
Proteome measurements with both cultured SAR11 cells and environmental samples from the Sargasso Sea and the Oregon Coast showed very high expression of ABC-transport systems in SAR11 cells [32] [34].
In the current study, we used solid tumors from a patient-derived xenograft (PDX) of prostate cancer with high expression of GRPr as a model system that appears homogenous on histological H&E stains with high receptor density throughout the tumor as detected by in vitro autoradiography, which led us to expect a high and homogeneous in vivo uptake throughout the tumor.
Infected OP9 cells were sorted for high expression of Strawberry detected by FACS Aria Special Order™ System using TxRed channel.
In our study, we provide the first comprehensive expression analysis of SAFB1 and SAFB2, showing high expression of both proteins in the immune system and in hormonally regulated organs.
BTSC exhibited remarkable resistance to chemotherapy due to their relative quiescence, active DNA repair regulatory systems and high expression of ABC transporters 80, 81.
QPX maximal growth at 23°C could then explain and justify the need for an efficient extracellular protein degradation and nutrient acquisition system associated with high expression of its digestive enzymes.
Selection of TRAIL-resistant cells by the continuous high expression of TRAIL is not unique to our system, since a recent report also describes the selection of TRAIL-resistant Jurkat subclones after continuous treatment with exogenously added recombinant TRAIL protein (Kim et al, 2001).
GM-CSF is commonly used in the preparation of DCs in vitro, and is associated with high expression of MR in both human and mouse systems.
