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It may be that the average is being inflated by other types of new drug, such as psychotropics, which may be only a bit more effective than existing ones but require big, expensive trials to gain approval.It is not only patients' groups and aid charities that are sceptical about the startlingly high estimates for drug-development costs that are bandied about.
No wonder when it went up for auction earlier this month at RM's Amelia Island, Fla., event, it sold for $1,375,000 far exceeding even the high estimates for a factory Lightweight E-Type.
Costs are very high; estimates for the year 2002, in fragility fracture patients aged >65 years, show that expenses are related both to surgical treatment and rehabilitation, while total costs for the year 2006 are estimated to be about 1,000,000,000 € in the same population.
The scale of milk production (even discounting the very high estimates for 2013) and the amount of milk that is currently collected by the milk bulking groups for the formal market (processors and microprocessors) suggests that actually the two studied strategies could coexist, even with the processing sector operating at full capacity.
The validation test of the Maxent package provided very high estimates for both training (0.976) and test (0.949) AUC (Table 1).
We see this clearly in Boonah, where it was acknowledged that there was underreporting early on and this led to us getting very high estimates for the initial reproductive number.
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There is supporting evidence for Mr Hussein's high estimate for Isis numbers.
The teddy bear mirror sold above its high estimate for $1.31 million.
That is slightly more than the high estimate, for once set at an unduly modest level.
Competition was stiff, and he had to pay more than the high estimate for three and just above the low for the fourth.
A Beijing collector paid $386,500, twice Christie's high estimate, for the privilege of returning the remarkable vessel to its homeland.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com