Sentence examples for high error frequency from inspiring English sources

While the genetic variability of polioviruses is mostly due to nucleotide substitutions resulting from a high error frequency during the replication of the viral RNA [14], genetic changes in polioviruses can also occur by molecular genomic rearrangement during virus replication [15].

Second, a high error frequency has been observed during viral RNA synthesis [ 24].

A sum score was calculated and dichotomised with the upper tertile indicating a comparatively high error frequency.

Coverage directly affects frequency (at a coverage of 100 a single erroneous mutation would result in a frequency of 1% but is unlikely to be trusted), whilst a site with poor quality could similarly lead to a high error frequency from machine miscalls alone.

RNA viruses have high error frequencies and our understanding of viral population dynamics has been shaped by quasispecies evolutionary theory.

Despite the high error frequencies induced by mutagen, mutations did not accumulate at random along the viral genome, but rather they accumulated at preferred genomic regions.

aVariances in number of cases due to missing data bn cM (SD) dChirurgisches Qualitätssiegel/Physician Achievement Review eA higher score indicates a higher error frequency The associations between both job stress models and the indicators of perceived quality of health care are displayed in Tables 3 and 4 by means of odds ratios and confidence intervals.

Too-high error frequencies caused by the application of mutagens can be detrimental and lead to "error catastrophe" [ 30].

Figure  3 displays the mutation spectra of the four experimental samples and represents a novel data set that measures the amount of error introduced during each stage of processing an RNA viral sample for sequencing, with the mutation spectrum shifting progressively towards higher error frequencies the more processing the viral sample undergoes.

Much effort has been applied to the development of computational methods for the de novo assembly of genomes using the type of data generated by these technologies: typically, shorter reads and/or higher error frequencies vs. traditional Sanger sequencing (Sanger et al. 1977; Glenn 2011).

They do so with extremely high fidelity, exhibiting an error frequency in the range of 1 in 10 10 mistakes per incorporation event depending on the presence or absence of an intrinsic exonuclease activity.