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Tailored therapy according to antibiotic resistance has been proposed for achieving a high eradication rate.
6 7 31 32 36 41 44 50 Previous data suggested a high eradication rate with sequential therapy in strains resistant to clarithromycin.
One randomized controlled trial in southern Taiwan reported a high eradication rate (92.9 % with PP and 93.2 % with ITT analysis) of sequential therapy [ 35].
5 Given the importance of eradicating H pylori infection in patients with ulcer disease, the infection should be treated optimally with a combination regimen that has an acceptably high eradication rate.
Recently, a new therapy consisting of proton pump inhibitor, amoxicillin 1 g, levofloxacin 500 mg, and tinidazole 500 mg, all given twice daily for five days, has been shown to reach a high eradication rate.
The same logic of low H. pylori density in stomach very well explains the quite high eradication rate assessed by fecal antigen detection, RUT, histology, single round PCR, and bacterial isolation methods.
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Similarly, endocarditis and bacteremia models showed adequate penetration into vegetations and high eradication rates from blood with oritavancin.
This regimen is also reputed to achieve high eradication rates over a shorter treatment duration than other regimens (Huang and Hunt, 1999).
Moxifloxacin has beneficial pharmacokinetic and pharmacodynamic properties, is strongly targeted to alveolar tissue, and demonstrates rapid initial killing with high eradication rates [ 48].
Because of the high eradication rates achieved in the pilot study, only a 10% sample will be retested to confirm successful treatment and indirectly act as a measure of adherence.
19 A novel hybrid treatment consisting of a dual treatment with a proton pump inhibitor and amoxicillin for seven days, followed by a concomitant quadruple treatment with a proton pump inhibitor, amoxicillin, clarithromycin, and 5-nitroimidazole for another seven days produces high eradication rates and represents a promising first line treatment option.
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