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CREKA-Lipo was uniformly formed with high entrapment efficiency.
ART-LNSs with high entrapment efficiency, small size of about 50 nm and monodispersity were formulated.
After freeze-drying, the prepared liposomes possessed high entrapment efficiency of more than 90%.
Thin film method and proliposome method provided high entrapment efficiency (92.9% and 97.4%, respectively).
The nanoparticles prepared by nanoprecipitation method were in nanometer size range with high entrapment efficiency and positive surface charge.
The D-optimal design was applied in order to reach micelles with high entrapment efficiency (EE %) and minimum size, simultaneously.
The thermoporometry studies revealed that the common interpretation of sharp intrusion curves and high entrapment levels in porosimetry data as implying ink-bottle pore geometries is flawed.
Various parameters such as lipid ratio and lipid to drug ratio were optimized by using Design-Expert® Software to obtain high entrapment with minimum vesicle size.
Mean particle sizes of ≤100 nm, high entrapment efficiency (EE, about 95%) and drug loading (DL, >3%) were obtained for the optimized formulations.
NLCs prepared by high-pressure homogenization technique following a factorial design had low particle size (<199 nm), high entrapment efficiency (∼90%), and long-term physical stability.
These conditions produced NPs of a size appropriate particle size for ocular administration (around 350 nm) and high entrapment efficiency (80%).
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