Sentence examples for high efflux from inspiring English sources

Thus, hAQP10 has potential for therapeutic intervention of obesity and metabolic diseases, as targeting the pH gate to allow constitutively high efflux of glycerol may prevent accumulation of TAGs inside adipocytes.

While potency on BACE-1 was rather high, the first set of compounds showed poor brain permeation and high efflux in the MDRI MDCK assay.

Very special and surprisingly different treatments, such as the addition of detergents, but also the addition of penicillin, are always required in order to obtain high efflux of l-glutamate.

Efforts to tackle low permeability and high efflux in our previously reported pyrrolopyrimidine series (Scott et al., 2017) led to the identification of pyrrolotriazines which contained one less formal hydrogen bond donor and were intrinsically more lipophilic.

The different compounds inducing a high efflux of GSH were evaluated on both sensitive and resistant cell lines, and two of them, belonging to the flavones class were found to be more cytotoxic on resistant cancer cells, with the best selectivity ratio >9.1.

He observed that there was a high glycolytic flux under anaerobic growth conditions, characterised by a high efflux of glyceraldehyde-3-phosphate (G3P) and fructose-6-phosphate from the pentose phosphate pathway (PPP) to the EMP pathway, resulting in the highest bioethanol production under these conditions.

The highest efflux rate was observed for the mHippoE-18 cells.

Finally, the parameter with the greatest difference between the iodine- and zirconium-labeled experiments was the efflux value, with 124I-J591 havery a very significant ninefold higher efflux rate of the radiolabel than that of 89Zr-J591 (p < 0.0000005) (Fig. 4).

SP cells are defined as cells that show higher efflux of chemicals including DNA-binding dye Hoechst 33342.

Another study also showed that Kit+ differentiating spermatogonia in the "side population", defined by the higher efflux of DNA-binding dye Hoeschst 33342, have SSC activity [32].

Again, as shown in Figure 4E, cells from CD36−/− mice effluxed more [14C]-cholesterol into the medium (p = 0.042), and had significantly higher efflux efficiency (p = 0.049, Fig. 4F).