Exact(8)
We observed a high duplicate reproducibility rate (99.98%), high Mendelian consistency rate (99.93%), and a low rate of missing genotypes (0.55%) in the data.
SA006 and SA035 do display an increased duplicate rate (54%, 78% respectively), but SA008 also displays high duplicate rate with minimal effect on mapping quality.
At the same time, the performance of PCR amplicon sequencing can be negatively affected by issues such as high duplicate reads, polymerase artifacts and PCR amplification bias.
Despite the high duplicate read fraction both samples in the whole exome capture experiment had 80% targeted of bases with at least 20x coverage.
A small portion of the genes in a genome has extraordinarily high duplicate counts, while the vast majority either are singletons or has only a few duplicates.
First, different from transcription factors and kinases, high duplicate retention rate after 2R-WGD didn't increase the tetraspanin family size but just reshaped the family composition.
Similar(52)
Genes in such fully diversified pairs, we found, overwhelmingly belong to large duplicate gene groups – they have higher duplicate counts (K) and thus higher duplicability.
This is the first report to show that tumor-associated miRNAs tend to have a higher duplicate incidence than other miRNAs, and of it is of note that miRNA tumor suppressors tend to have a higher duplicate incidence than miRNA oncogenes.
Pilot 1 likely has a higher duplicate rate due to lower DNA quality (see below).
The highest duplicate rate was identified in the phase 1 cancer cohort (mean = 79.9%, range = 65.8%91.2%%).
The higher duplicate gene retention rates due to enhanced diversifiability in turn leads to increases in duplicate gene abundance from prokaryotes to multicellular eukaryotes.
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