Sentence examples for high dosing from inspiring English sources

Ourresearch objective was to design a new form of IL-7 that retained its capacity for supporting lymphocyte expansion without the need for a high dosing regimen.

For instance, lapaquistat (TAK-475, Takeda), a SS inhibitor, progressed to phase III clinical trials, although its outcome in cancer remains to be established due to hepatotoxic effects at high dosing [276].

However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desire for sustained prevention.

The objective of this study was to describe the pharmacokinetics of tigecycline in critically ill patients receiving continuous venovenous haemodialysis (CVVHD) and to evaluate the frequency of pharmacokinetic/pharmacodynamic target attainment with high dosing strategy (200 mg loading dose and 100 mg/100).

Dosing simulations for amikacin supported the use of high dosing regimens (≥25 mg/kg) and extended intervals (36 to 48 h) for most patients to achieve the pharmacodynamics/pharmacokinetics target of peak/MIC ≥ 8 for efficacy and the lowest probability of target attainment (PTA) of a minimal concentration ≥ 2.5 mg/L for toxicity.

Similar results have been reported for other plants experiencing high dosing (Cao et al., 2007, 2009a).

High doses can cause fatal renal failure.

In high doses, aflatoxins can be deadly.

Those on the high dose lost 10.6 percent.

We know what happens at high doses.

Frequent high doses of THC may overstimulate the endocannabinoid system.