Exact(46)
The high dose was 5 times as much as the middle dose.
Clinicians, Dr. Recker said, "were told without adequate data that the minimum dose for protecting bones was.625 milligrams of estrogen, yet at the same time such a high dose was not tolerated in the elderly".
The results indicated that the cells were highly saturated when a high dose was applied, while for a low dose saturation was only reached in 5% of the simulations.
The high dose was the amount shown in a previous study of the guinea pig to slow the progression of surgically induced OA.
Cardiac SAE were delayed onset in three patients (72, 71 and 24 months after the very high dose was achieved).
Cardiac NSAE was delayed onset in five patients (60, 36, 27, 24 and 24 months after the very high dose was achieved).
Similar(14)
"A high dose is essential," Hoffmann-La Roche medical director Mark Kunkel said, stressing that he had no independent knowledge of the experiment.
A study in the journal Blood in 2006 compared patients in the Netherlands, where a low dose is used, to those in Germany, where a high dose is typical.
"It shows that GDNF at this high dose is safe".
This high dose is safe; no patients required discontinuation or dose reduction.
The folic acid in very high doses was well tolerated.
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