Additionally, we define an upper dose bound for PTV as (D_{1}^{mathrm{U}}> D_{1}^{mathrm{L}}) to avoid excessively high dose values inside the PTV.
The use of seven 500L SUBs per lot allows the manufacture of up to 5,000 doses/lot for a dose of 10 cells (Fig. 2c) but this value drops to 1,000 doses/lot for higher dose values of 10 cells (Fig. 2d).
Total plasma area under the curve (AUC0-infinity) was increased by 22%, but was still less than 50% of the unheated high-dose value.
Investigation of a high personal dose value begins with a check of the validity of the dosimeter reading.
SHAM = Sham-operated control rats; OVX = ovariectomised non-honey treated control rats THL = Tualang Honey, low dose; THM = Tualang Honey, medium dose; THH = Tualang Honey, high dose All values are expressed as the median (IR).
*P < 0.05 and **P < 0.01 vs. OVX (Mann-Whitney U - test) SHAM = Sham-operated Control rats; OVX = overictomised non-honey treated Control rats THL = Tualang Honey, low dose; THM = Tualang Honey, medium dose; THH = Tualang Honey, high dose All values are expressed as the median (IR).
The acute toxicity study demonstrated that PPE was practically nontoxic based on its high median lethal dose value (LD50 = 10.25 g/kg).
The highest mean absorbed dose value estimated from the mouse data was observed in the small intestine (38.5 μGy/MBq), liver (25.5 μGy/MBq) and urinary bladder wall (43.1 μGy/MBq).
'High dose' referred to values that were greater than or equal to the average daily dose, while 'low dose' referred to values that were less than the average daily dose; cFrom 1 year prior to cohort entry until the end of the study; SD = standard deviation; IQR = interquartile range.
To differentiate between treatment intensity, the patients were categorized into three groups of treatment intensity, i.e. not on actual drug, low dose defined as daily dose ≤ median value and high dose defined as daily doses > median values.
Antioxidant enzyme GPx showed significantly decreased activity with the low and high dose (Kruskal-Wallis chi value 11.5, P = 0.007), GRed showed a significant reduction with the dose (Pearson coefficient = −0.61; P = 0.01), and SOD also exhibited a decreased activity related with the treatments (Pearson coefficient = −0.75; P = 0.002), while CAT showed nonsignificant reductions with treatments.
