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Additionally, the high dose of type I IFNs was immunosuppressive.
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Furthermore, immunized mice challenged with a high dose of wild type virus were completely protected from morbidity and mortality.
Mice inoculated with a high dose of the wild-type virus resulted in a 45.5% (5/11) survival, whereas 90.9% (10/11) of the mice survived after infection with the same dose of the R292K variant after 15 days of observation (P=0.018).
We know that the offspring of exposed rats suffer reduced motor function, and that some develop tumors at high doses of one type of PBDE.
However, high doses of intratumoral type I IFNs largely function via an anti-angiogenic effect.
Those studies have one similarity to the Penn experiment that worried regulators: They use relatively high doses of a type of cold virus called adenovirus to slip new genes directly into the liver.
Also, a recent study showed that, in a 5/6 nephrectomy model, delayed treatment with high doses of a type 1 angiotensin II receptor antagonist led to regression of glomerulosclerosis, possibly by inhibiting PAI-1 and modulating extracellular matrix turnover [53].
We hypothesize that for patients with severe hypotension, lower doses of multiple vasopressors with differing mechanisms of action may be more efficacious and less toxic than high doses of one type of vasopressor (that is, catecholamines).
High doses of angiotensin type 1 receptor (AT1R) blocker losartan (LST) seem to promote fat cell formation by preserving PPARγ activity.
These rats with high dose of STZ resembled more like type 1 diabetes.
However, in some cases, introduction of a high dose of TALEN mRNA with heterodimer type FokI, (500∼800 pg) exhibits high toxicity and rate of developmental defects in X. tropicalis (Lei et al., 2012).
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