Dr. Boockvar said microcatheters should increase the odds of success by delivering a high dose of the drug directly to where it was needed most.
The former agent, Alexander V. Litvinenko, died in London in November after ingesting a high dose of the radioactive isotope polonium 210.
In the Lancet study, by researchers from the United States and from Canada's National Microbiology Laboratory in Winnipeg, eight monkeys were injected with an extremely high dose of the virus.
In 2013, she began suffering psychotic episodes and said she was hearing voices, possibly linked to the high dose of the stimulant drug, modafinil, that she was prescribed to help her stay awake.
Men in this study received a high dose of the ADT drug bicalutamide, which doctors use less frequently for PSA recurrence today, instead favoring other testosterone-suppressing medications that have since been shown to be more effective.
The authorities investigating the killing of Alexander V. Litvinenko, the former K.G.B. officer who died in London in November of a high dose of the radioactive isotope polonium 210, said they had detected radiation contamination at a restaurant in the Mayfair district of London.
After waiting eight months for results of a toxicology test, then spending two more years pressing the coroner and hospital officials to explain why Mr. Schramm had an unusually high dose of the drug digoxin in his blood, family members filed a lawsuit in 2001 claiming that Easton had given him negligent care.
Some experts called it an anomaly, and pointed to the fact that the trial's participants were sicker than patients in earlier testosterone studies and were treated with a relatively high dose of the hormone.
Here, we evaluated the consequences of a high dose of the MAGL inhibitor JZL184 [4-nitrophenyl 4- dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate; 4- dibenzo[dven acutely or for 6 days in FAAH and mice.
Most strikingly, in mice treated with a high dose of the drug (5 mg/kg) the structure of the RPE and Bruch's membrane and the normal architecture of photoreceptor outer segments were preserved.
An enriched design can also be used in which patients successfully converted to a high dose of the study drug, are then randomised to either the high or low dose of the treatment.
