Sentence examples for high dose of nitrate from inspiring English sources

Interestingly, at the high dose of nitrate supplementation, the anemic response was partially reversed (Fig. 3 C ). Arterial Hb-O2 saturation was not affected by nitrate (Supplemental Fig. 2 D ).

C-palmitate oxidation per unit of mitochondrial protein was increased by nitrate supplementation, though this only reached statistical significance at the highest dose of nitrate (Fig.  2e).

Increased mitochondrial volume density was observed at the highest dose of nitrate used in this study, supporting the capacity of muscle for complete FA oxidation.

Meanwhile, HOAD activity showed a similar pattern, with no effect of low or medium doses of nitrate supplementation, but 86 % higher activity at the highest dose of nitrate (Fig.  2d).

At the highest dose of nitrate used, PPARβ/δ expression and PPARβ/δ-DNA binding fell below that of lower doses, though PPARα expression and DNA-binding activity was highest.

Given the elevation in plasma nitrite levels observed at the higher dose of nitrate supplementation, it is possible that the rise in Hb at this dose was accompanied by enhanced local formation of methemoglobin (MetHb) via an interaction between Hb and nitrite; however, plasma concentrations of nitrate and nitrite, even at this highest dose, remain below those required to induce methemoglobinemia.

In agreement, at the medium dose of nitrate used in the present study, at which Hb concentrations were lowest, we observed greater expression of HIF1 α and HIF2 α in the kidney; however, renal HIF levels were normalized in rats treated with the higher dose of nitrate, when the relative anemia was alleviated.

Animal studies have found adverse reproductive effects resulting from higher doses of nitrate or nitrite.

The renal brake on this mechanism, as demonstrated here by higher doses of nitrate supplementation, is likely to be mediated by hypoxia-sensing pathways that are activated following relative anemia, thereby averting a detrimental fall in oxygen-carrying capacity.

Thus, although the changes in PGC-1α were not associated with significant changes in citrate synthase activity, our findings nevertheless suggested that nitrate may exert effects on mitochondrial biogenesis via PGC-1α, and that this might become apparent with higher doses of nitrate.

Plus, a high dose of antibiotics.